加拿大批准基于工厂的Covid-19 Vax

加拿大卫生加拿大已授予Covifenz,这是由Medicago和Glaxosmithkline(GSK)开发的植物的Covid-19疫苗。

Covifenz is made up of plant-based virus-like particles (VLP) and aims to prevent COVID-19 caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in individuals between the ages of 18 to 64 years old.

Medicago uses its Proficia technology to synthesize the virus’ code once a virus has been genetically sequenced. In doing so, the firm claims its genetic instructions can then be “read” by plants.

“In the plant-based vaccine development process, living plants are used as bioreactors to produce a non-infectious VLP that mimics the target virus,” Brian Ward, medical officer at Medicago told生物过程内幕

Image: Stock Photo Secrets

The Proficia technology uses Nicotiana benthamiana根据Medicago的植物是植物病毒学中使用的最广泛使用的实验宿主,因为大量的病毒可以成功地感染它。因此,临时剥削尼古利亚纳·施坦南亚的天然细胞过程以生产VLP。

Ward told us that a pivotal aspect for the development of its plant-based vaccine “is centered on our greenhouses.” After the synthesis process has taken place, the code is inserted into a bacterial vector, and they submerge plants into a bacterial bath. Then, using a vacuum, the air inside the plants’ intercellular space is removed and liquid is absorbed by the plants.

该植物将开始产生VLP,并将其放入受控温室至少四天,以迅速产生大量的VLP。此后,收获植物,提取VLP。然后将植物叶片混合成额外VLP的溶液。最后,纯化颗粒并测试无菌和质量。

疫苗还使用GSK的大流行辅助系统在对此进行了开发疫苗之后7月2020年7月。GSK claims that the use of an adjuvant can be important in a pandemic situation as it could potentially boost the immune response and decrease the amount of antigen required per dose, meaning larger amounts of vaccines can be produced.

厂优势

虽然病房不会将Covifenz与其他可用的Covid-19疫苗进行比较,因为Medicago“没有执行头脑比较”,他确实列出了以下基于植物疫苗的优势:

  • 敏捷:一旦Medicago接受了病毒菌株,我们就可以在大约19天内生产匹配的VLP。
  • 准确:能够与VLP密切匹配目标菌株。
  • 多功能:使用同一平台生产疫苗和治疗剂的能力。
  • High-quality: Stringent purification and quality controls are built in at every stage.

The Canadian government has a contract with Quebec-based firm Medicago to supply the COVID-19 vaccine, which the firm says it is committed to fulfilling as soon as possible.

此外,保健加拿大表示,其授权Covifenz的决定是基于科学数据,该数据是Medicago作为其滚动提交的一部分,该数据于2021年开始。

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